Latest Advances in UHPLC Column Technology

Since its commercialization in 2004, ultra-high-performance liquid chromatography (UHPLC) technology has driven continuous innovation in column packing materials, enabling breakthroughs in separation performance.

Sub-2 Micron Filler Technology

1.7 μm and even 1.3 μm fully porous silica beads are now commercially available, achieving column efficiencies exceeding 200,000 N/m—a 3-fold improvement in resolution compared to traditional 5 μm particles.

Core-shell particle technology

Core-shell particles (e.g., Kinetex, Cortecs) offer 30% higher column efficiency than fully porous particles at the same particle size due to reduced eddy diffusion and faster mass transfer rates.

Surface chemical modification

The introduction of new bonded phases, such as Charged Surface Hybrid (CSH) and Polar-Embedded technologies, has significantly improved peak shapes for basic compounds and polar molecules.